ParkinsonCanadaV1, Main, Exploration, bibRecord, 000704

Head injury at early ages is associated with risk of Parkinson's disease

Identifieur interne : 000704 ( Main/Exploration ); précédent : 000703; suivant : 000705

Head injury at early ages is associated with risk of Parkinson's disease

Auteurs : Kathryn M. Taylor [États-Unis] ; Marie-Helene Saint-Hilaire ; Lewis Sudarsky ; David K. Simon ; Bonnie Hersh ; David Sparrow [États-Unis] ; Howard Hu ; Marc G. Weisskopf

Source :

Parkinsonism & related disorders [ 1353-8020 ] ; 2015.

RBID : PMC:4787263

English descriptors

KwdEn :
- Adolescent, Aged, Case-Control Studies, Child, Craniocerebral Trauma (complications), Craniocerebral Trauma (epidemiology), Female, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease (etiology), Risk Factors, Surveys and Questionnaires.
MESH :
- complications : Craniocerebral Trauma.
- epidemiology : Craniocerebral Trauma.
- etiology : Parkinson Disease.
- Adolescent, Aged, Case-Control Studies, Child, Female, Humans, Male, Middle Aged, Odds Ratio, Risk Factors, Surveys and Questionnaires.

Abstract

Introduction

The literature on the effect of head injuries on the risk of PD is inconclusive. Some researchers have hypothesized that studies that have seen an effect are simply capturing injury related to pre-clinical PD. However in animal models brain inflammation, which can be initiated by head trauma, has been shown to produce PD-like effects. Furthermore, animal studies have found that early life inflammation in particular is of relevance for PD pathology.

Methods

We conducted an unmatched case-control study of 379 neurologist confirmed PD patients and 230 controls from the greater Boston, Massachusetts area with questionnaire data on history of head injury and other covariates. We used multivariable logistic regression to estimate adjusted odds ratios (OR) and their corresponding 95% confidence intervals (CI) for PD.

Results

When we excluded injuries that occurred less than 10 years prior to the diagnosis of PD (in order to avoid reverse causation), we found an increased risk of PD associated with a head injury that resulted in a loss of consciousness, but it did not reach statistical significance (OR= 1.57; 95% CI= 0.89-2.80). We found a significant (p=0.04) effect of age at first head injury. For every 5 year earlier age at first head injury with loss of consciousness the OR for PD was 1.37 (95% CI: 1.01-1.86).

Conclusion

Our results suggest that head injury in early life increases the risk of PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787263

DOI: 10.1016/j.parkreldis.2015.12.005
PubMed: 26725141
PubMed Central: 4787263

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">The literature on the effect of head injuries on the risk of PD is inconclusive. Some researchers have hypothesized that studies that have seen an effect are simply capturing injury related to pre-clinical PD. However in animal models brain inflammation, which can be initiated by head trauma, has been shown to produce PD-like effects. Furthermore, animal studies have found that early life inflammation in particular is of relevance for PD pathology.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We conducted an unmatched case-control study of 379 neurologist confirmed PD patients and 230 controls from the greater Boston, Massachusetts area with questionnaire data on history of head injury and other covariates. We used multivariable logistic regression to estimate adjusted odds ratios (OR) and their corresponding 95% confidence intervals (CI) for PD.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">When we excluded injuries that occurred less than 10 years prior to the diagnosis of PD (in order to avoid reverse causation), we found an increased risk of PD associated with a head injury that resulted in a loss of consciousness, but it did not reach statistical significance (OR= 1.57; 95% CI= 0.89-2.80). We found a significant (p=0.04) effect of age at first head injury. For every 5 year earlier age at first head injury with loss of consciousness the OR for PD was 1.37 (95% CI: 1.01-1.86).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Our results suggest that head injury in early life increases the risk of PD.</p>
</sec>
</div>
</front>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Taylor, Kathryn M" sort="Taylor, Kathryn M" uniqKey="Taylor K" first="Kathryn M." last="Taylor">Kathryn M. Taylor</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Head injury at early ages is associated with risk of Parkinson's disease

Head injury at early ages is associated with risk of Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.